Medicine

Cigarette smoke causes cancer primarily by damaging the DNA. A new study that mapped the DNA damages caused by smoking, reveals that the way our DNA is organized and chemically modified can influence how cigarette smoke damages it, how well the damage is repaired and how many mutations will form. Specifically, areas of DNA that are more open and active are more prone to damage but also better at repairing themselves, which helps to prevent mutations.

Researchers have uncovered how egg cells prepare for the creation of life. Their work reveals the secrets of the Balbiani body, a remarkable structure that organizes essential molecules to guide early embryonic development. Using zebrafish models and cutting-edge imaging, the team discovered how this structure transforms from liquid droplets into a stable core, laying the groundwork for life itself. This discovery sheds light on the extraordinary precision of nature’s reproductive process. 

A new study has uncovered a surprising link between Alzheimer’s disease and Herpes Simplex Virus-1 (HSV-1). Researchers found HSV-1 proteins embedded in Alzheimer’s brains, revealing how the virus is inhibited by tau protein—a key player in the disease. These insights could pave the way for innovative treatments targeting viral activity and the brain’s immune response to slow or even stop Alzheimer’s progression.

Researchers at the Hebrew University enhanced the Elixhauser Comorbidity Model, improving predictions for length of hospital stay, mortality, readmission, and escalated care. The study outperformed the standard Elixhauser model, offering a comprehensive view of patient complexity. These findings benefit healthcare decisions and patient outcomes, with broad implications for the field.

New study suggests that low-level laser therapy (PBM) offers immediate pain relief for Burning Mouth Syndrome (BMS) patients. Over 10 weeks, 30 participants experienced a significant drop in pain scores after each treatment. While efficacy decreased in the following week, a cumulative effect was observed, especially up to the third treatment. The findings highlight the potential of PBM as a promising treatment for BMS, despite some nuances in its effectiveness.

Research introduces new DNA methylation-based method for accurately assessing cell composition in the human pancreas, addressing a critical gap in diabetes research. By overcoming limitations of traditional protein marker-based approaches, the study provides a more precise means to identify specific cell types. The findings offer insights into beta-cell dysfunction across diabetes types and have direct clinical implications, enhancing our understanding of diabetes development and potentially guiding more tailored treatment strategies.

Antibiotic resistance is a growing public health concern with global implications. Antibiotic-resistant infection affects over 2.8 million individuals each year in the United States alone, resulting in more than 35,000 annual deaths. New resistance mechanisms constantly emerge and spread globally, threatening our ability to treat common infectious diseases, such as pneumonia, tuberculosis, and sepsis.

An international team led by Professor Hagai Levine of Hebrew University of Jerusalem’s Hadassah Braun School of Public Health, with Prof. Shanna Swan at the Icahn School of Medicine, Mount Sinai, New York, along with researchers in Denmark, Brazil, Spain, Israel and the USA, published the first meta-analysis to demonstrate declining sperm counts among men from South and Central America, Asia and Africa.

The Hebrew University of Jerusalem (HU) climbed 13 places to rank 77^th among the world’s top universities and number one in Israel, according to the 2022 Academic Ranking of World Universities (ARWU), published today (Monday).  Topping the list were Harvard, followed by Stanford, MIT, Cambridge, and UCLA Berkeley.  Two other Israeli universities placed in the top 100, as well—the Technion and Weizmann Institute both shared the 83^rd spot.  This is a major achievement for Israel’s higher education at large and for Hebrew U., specifically.

With a Constant Renewal of Cell Vitality in Diseased Tissues, This New Drug Will Hopefully Lead to the Treatment or Prevention of Diseases, Such As Alzheimer’s and Parkinson’s

Hebrew University & Hadassah Medical Center Researchers Attribute Discrepancy in Pain Med Prescriptions at Emergency Rooms in US and Israel to Reduced Empathy