Medicine

A surprising new drug combo—including a compound found in chocolate—has outperformed Tamiflu in fighting the flu, according to a study published in PNAS. The mix of Theobromine and Arainosine proved far more effective against a range of flu strains, including drug-resistant versions of bird and swine flu. By targeting a key viral weakness, this breakthrough could lead to stronger, longer-lasting treatments—not just for the flu, but potentially for other viruses as well.

Researchers have discovered a way to make the immune system’s T cells significantly more effective at fighting cancer. By blocking a protein called Ant2, they were able to reprogram how these cells consume and generate energy—essentially rewiring their internal power supply. This shift makes T cells more active, resilient, and better at attacking tumors. The findings open the door to new treatments that could strengthen the body’s own immune response, offering a smarter, more targeted approach to cancer therapy.

The Hebrew University of Jerusalem is proud to announce a new international agreement with the Faculty of Dentistry at the Graduate School of Medical and Dental Sciences, Institute of Science, Tokyo. This agreement marks the beginning of a collaborative partnership focused on research, and the mutual exchange of students and academic staff.

The Tokyo institute is globally recognized for excellence. Its Faculty of Dentistry holds an impressive 4th place in QS 2025 Subject Rankings!

Why do so many people relapse after quitting cocaine? A new study from The Hebrew University reveals that a specific “anti-reward” brain circuit becomes hyperactive during withdrawal—driving discomfort and pushing users back toward the drug. Surprisingly, this circuit may also serve as a built-in protective mechanism, offering new hope for addiction treatment.

In a major stride toward tackling aggressive breast cancer, researchers from The Hebrew University of Jerusalem have developed druglike molecules that degrade a previously “undruggable” cancer-driving protein. The target, HuR—an RNA-binding protein known for stabilizing oncogenic messages—has long eluded traditional therapies. Now, using next-generation strategies involving molecular glues and PROTACs, researchers have uncovered a promising route to disarm HuR and suppress tumor growth from the inside out.

A new study has uncovered how stress experienced by mothers during pregnancy leaves a molecular imprint on their babies—starting before birth. The research shows that prenatal stress alters the expression of tiny RNA molecules in newborn blood, particularly in female children, and affects key enzymes in the brain's stress-regulation system. These changes may help explain why some children are more vulnerable to developmental or psychiatric challenges. The study opens new possibilities for early diagnosis and interventions targeting stress-related health risks.

A promising new discovery from the Hebrew University of Jerusalem reveals that cross-linked hyaluronic acid (XHA) significantly enhances the retention and concentration of topical antibiotics in the tear film of dogs. Compared to traditional formulations using polyvinyl alcohol (PVA), the XHA-based eyedrops maintained higher drug levels for longer durations. This innovation not only suggests improved treatment outcomes for veterinary patients – it also carries meaningful implications for human medicine.

Cigarette smoke causes cancer primarily by damaging the DNA. A new study that mapped the DNA damages caused by smoking, reveals that the way our DNA is organized and chemically modified can influence how cigarette smoke damages it, how well the damage is repaired and how many mutations will form. Specifically, areas of DNA that are more open and active are more prone to damage but also better at repairing themselves, which helps to prevent mutations.

Researchers have uncovered how egg cells prepare for the creation of life. Their work reveals the secrets of the Balbiani body, a remarkable structure that organizes essential molecules to guide early embryonic development. Using zebrafish models and cutting-edge imaging, the team discovered how this structure transforms from liquid droplets into a stable core, laying the groundwork for life itself. This discovery sheds light on the extraordinary precision of nature’s reproductive process. 

A new study has uncovered a surprising link between Alzheimer’s disease and Herpes Simplex Virus-1 (HSV-1). Researchers found HSV-1 proteins embedded in Alzheimer’s brains, revealing how the virus is inhibited by tau protein—a key player in the disease. These insights could pave the way for innovative treatments targeting viral activity and the brain’s immune response to slow or even stop Alzheimer’s progression.

Researchers at the Hebrew University enhanced the Elixhauser Comorbidity Model, improving predictions for length of hospital stay, mortality, readmission, and escalated care. The study outperformed the standard Elixhauser model, offering a comprehensive view of patient complexity. These findings benefit healthcare decisions and patient outcomes, with broad implications for the field.

New study suggests that low-level laser therapy (PBM) offers immediate pain relief for Burning Mouth Syndrome (BMS) patients. Over 10 weeks, 30 participants experienced a significant drop in pain scores after each treatment. While efficacy decreased in the following week, a cumulative effect was observed, especially up to the third treatment. The findings highlight the potential of PBM as a promising treatment for BMS, despite some nuances in its effectiveness.